Stress, overstimulation, or adverse drug reactions from drugs like Modalert 200 might be the cause of your brain’s inability to go asleep Modalert, a medication that promotes alertness and is frequently used to treat sleep apnea or narcolepsy, keeps you awake by raising dopamine levels. Modalert 200 works well throughout the day, but if you take it too late, it might disrupt your brain’s natural sleep cycle and make it difficult to fall asleep at night. Your brain may also be kept busy by other things like coffee, worry, or exposure to blue light. Restoring healthy, restful sleep requires controlling dose timing, stress levels, and sleep hygiene.